From Northern Pinellas County:

Drive south on U.S. 19
Turn left (east) at 5th Avenue South
Turn right at 6th Street South
Bayfront Medical Center will be on your right

From Southern Pinellas County:

Drive north on U.S. 19
Turn right (east) at 5th Avenue South
Turn right at 6th Street South
Bayfront Medical Center will be on your right

From Tampa:


Drive west on the Howard Franklin Bridge
Merge onto I-175 East Exit 22 on the left
toward Tropicana Field
Exit toward 6th Street South
Turn right (south) on 6th Street South
Bayfront Medical Center will be on your right